1. Treating cold, sore throat and mild pain relief, antibacterial, anti - inflammatory.

2. Making people energetic and calm.

3. In Thailand and Myanmar Combretum quadrangulare is used as an energy booster, like caffeine or “energy drinks”.

Sakae Naa (Combretum quadrangulare) is a relatively unknown herb made from the leaves of the tree with the same name. The tree is found in various jungles and wetlands throughout Southeast Asia.
The extract is used in China as herbal medicine for common colds, sore throats and mild pain relief. Independent studies have confirmed the anti-bacterial and anti-inflammatory properties. Properties which the Combretum quadrangulare tree shares with other species in the Combretum family.
Sakae Naa is used by many people in Thailand and Myanmar though it is reportedly seldom sold. Farmers pick the leaves themselves and chew or smoke them, using it as a substitute for Mitragyna speciosa because Sakae Naa is remarkably similar to it in both look and taste. The effects are energizing and mildly sedating and last up to 4 hours.