DETAILS
Bortezomib
It is indicated for the treatment of relapsed multiple myeloma and mantle cell lymphoma. It is capable of inhibiting
the mammalian 26S proteasome, which is important in regulating the intracellular concentration of specific proteins
to maintain homeostasis within cells. The disruption of 26S proteasome function disrupts normal cellular homeostasis,
leading to cytotoxic effect on various kinds of cancer cells.
| Product name | Bortezomib |
| CAS | 179324-69-7 |
| Appearance | white powder |
| Assay | 99% |
| Storage | Cool and Protect from light |
Bortezomib, a modified dipeptidyl boronic acid, is a therapeutic proteasome inhibitors used for the treatment of cancers. It is indicated for the treatment of relapsed multiple myeloma and mantle cell lymphoma. It is capable of inhibiting the mammalian 26S proteasome, which is important in regulating the intracellular concentration of specific proteins to maintain homeostasis within cells. The disruption of 26S proteasome function disrupts normal cellular homeostasis, leading to cytotoxic effect on various kinds of cancer cells.
1.Multiple myeloma
This product can be used in combination with melp halan and prednione (MP regimen) for the treatment of multiple myeloma patients who have not previously been treated and are not suitable for high-dose chemotherapy and myelosuppression; Or more than one treatment of relapsed patients with multiple myeloma.
2.Mantle cell lymphoma
This product can be used for the treatment of patients with relapsed or refractory mantle cell lymphoma. This patient received at least one treatment before using this product.
Certificate of Analysis
| Batch Number | Z20190412001 | ||
| Production Date | 2019.04.12 | ||
| Batch Quantity | 80 KGS | ||
| Item | Test Standard | Testing Result | |
| Appearance | Powder | Complies | |
| Color | white Powder | Complies | |
| Particle Size | 100% pass 80 mesh | Complies | |
| Oder | Characteristic | Complies | |
| Taste | Characteristic | Complies | |
| Loss on Drying | ≤5.0% | 2.20% | |
| Residue on Ignition | ≤0.1% | 0.05% | |
| Residual acetone | ≤0.1% | Complies | |
| Residual Ethanol | ≤0.5% | Complies | |
| Heave Mentals | ≤10ppm | Complies | |
| Na | ≤0.1% | <0.1% | |
| Pb | ≤3 ppm | Complies | |
| Total Plate | <1000CFU/g | Complies | |
| Yeast & Mold | <100 CFU /g | Complies | |
| E. Coli | Negative | Complies | |
| Salmonella | Negative | Complies | |
| Conclusion: Conform with USP Standard | |||
Storage:Closed container. dry & cool. keep away from moisture &strong light
Shelf life:24 Months
